Apolipoprotein-E (APOE) genotyping predicts Alzheimer's Disease (AD) with 100% accuracy in US study
This article was originally published in Clinica
Executive Summary
US researchers at Duke University Medical Center, North Carolina, found that apolipoprotein-E genotyping had a 100% positive predictive value in 57 demented patients confirmed by post mortem as having Alzheimer's disease. Reporting their results in the Lancet (July 13th), Prof A Roses and colleagues say that both the specificity and positive predictive value associated with the e4 allele were 100% for AD. None of the 10 demented non-AD patients carried the allele, while all the patients with APOE-e4 had AD. The negative predictive value was 42%.