Japan study finds in-stent restenosis susceptibility markers:
This article was originally published in Clinica
Executive Summary
A Japanese team has identified gene markers that could predict which patients who receive bare metal stents are more likely to develop in-stent restenosis. Researchers from the Gifu Prefectural Tajimi Hospital assessed 461 unrelated Japanese individuals who underwent coronary stent implantation, of which 107 subjects went on to develop in-stent restenosis. The genotypes for 142 polymorphisms of 121 candidate genes were determined using a method that combines polymerase chain reaction and sequence-specific oligonucleotide probes with suspension array technology. The BCHE, GPX1, and ROS1 genotypes were found to be independently associated with in-stent restenosis, the researchers revealed at last week's European Society of Cardiology 2007 meeting in Vienna, Austria.