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Phase III Trial Of Cerevast’s Transcranial Ultrasound To Treat Stroke Misses Endpoint

 
• By Reed Miller

The 90-day results of CLOTBUST ER, published in The Lancet, show sonothrombolysis to treat acute ischemic stroke is feasible and probably safe, but the trial did not show a clinical benefit of the therapy in conjunction with alteplase treatment.

Ischemic stroke : ( CT of brain show cerebral infarction at left frontal - temporal - parietal lobe ) ( nervous system background ) - Image
• Source: shutterstock.com

The authors of the randomized CLOTBUST ER trial of Cerevast Therapeutics Inc.’s sonothrombolysis system believe the pulsed-wave intracranial ultrasound technology could be used to improve the exposure of intracranial thrombus to alteplase (recombinant tissue plasminogen activator) and potentially facilitating early reperfusion.

But the 90-day results from CLOTBUST ER trial did not show a benefit of the therapy in patients with acute ischemic stroke.

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