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At HRS, Topera Topples Conventional Wisdom About Atrial Fibrillation

Topera Medical questions the assumptions underlying current therapies for atrial fibrillation. Sanjiv Narayan, MD, PhD, the electrophysiologist who founded Topera, has developed a means of identifying focal sources of aberrant electrical activity called rotors, and in late breaking clinical trials at the 2013 annual meeting of the Heart Rhythm Society, was able to show a definitive link between their ablation and treatment success.

Atrial fibrillation has always been frustratingly resistant to a cure. Even among the so-called easiest groups of patients, those with paroxysmal atrial fibrillation (which is intermittent and terminates on its own), conventional ablation procedures using radiofrequency or some other energy modality to scar the heart and isolate the instigating electrical impulses (or triggers) provide long-term freedom from AF only 50% of the time. The search for better efficacy is compelling because patients that suffer from atrial fibrillation have a five to seven-fold increased risk for stroke.

While much of the cardiology industry has tried to improve the results by incrementally improving the therapies, Topera Medical Inc. challenges the assumptions upon which therapy has been based....

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