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EndoSphere Inc.

Endoscopic duodenal insert regulates appetite

This article was originally published in Start Up

Executive Summary

EndoSphere Inc.’s SatiSphere duodenal insert is designed to fill a niche between permanent, expensive bariatric surgery and diet and exercise. The device is a small, C-shaped nitinol memory wire that incorporates braided spheres, or "speed bumps," along its length. It is delivered endoscopically through the esophagus to the duodenum. The braided structure of the spheres serves to hold food there temporarily, thereby keeping it in contact with nerve receptors for a longer period as it is released from the stomach during digestion. This causes an early feeling of satiety, and extends that feeling between meals.

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Obesity Devices: The Next Wave

Several emerging medtechs are developing products and procedures that are less invasive, less expensive, easier to deliver, and more easily reversible than bariatric surgery. With support from investors and the FDA, these firms are poised to reap big rewards in the massive, undermet obesity market.

Vibrynt Inc.

Vibrynt Inc.’s adjustable VIBRYNT PREVAIL Implant System is a saline-filled, silicone bladder designed to limit the stomach's ability to expand beyond the size of a small tube, and thus limit food consumption and calorie intake. The permanent implant is placed laparoscopically on the top of but still outside the stomach, and is designed to occupy the space that the stomach would normally expand to as a meal is eaten. Unlike the currently available surgical options, with the Vibrynt system there is no altering of the gastrointestinal anatomy and there are no restrictions on the types of healthy foods patients can eat.

Aspire Bariatrics Inc.

An ideal minimally invasive bariatric technology should be safe, easily implantable, suitable as a permanent therapy, and allow patients to eat a normal diet. Aspire Bariatrics Inc. thinks its solution fits the bill. With the AspireAssist Aspiration Therapy System, patients have control over their weight loss as they are able, about 20 minutes after a meal, to drain a portion of their stomach contents through an endoscopically implanted tube, thus reducing the number of calories absorbed by the body.

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