Medtech Insight is part of Pharma Intelligence UK Limited

This site is operated by Pharma Intelligence UK Limited, a company registered in England and Wales with company number 13787459 whose registered office is 5 Howick Place, London SW1P 1WG. The Pharma Intelligence group is owned by Caerus Topco S.à r.l. and all copyright resides with the group.

This copy is for your personal, non-commercial use. For high-quality copies or electronic reprints for distribution to colleagues or customers, please call +44 (0) 20 3377 3183

Printed By


The Knee Market Begins to Bend for Start-Ups

This article was originally published in Start Up

Executive Summary

The $4.6 billion worldwide market for knee arthroplasty is technologically mature, but it is underpenetrated today and it's still growing at a robust 14% annual rate. Furthermore, changes in demographics and patient expectations have created a large, unmet clinical need: the 50-something year old with unbearable knee pain. Today, that is the focus of a great deal of technological innovation-most of it incremental-on the part of large companies that seek to increase the longevity of devices with wear-resistant materials, and technologies that improve device fit, or the precision of placement and the accuracy of alignment of implants. But recently, and somewhat surprisingly, venture-backed start-ups have also begun to enter joint reconstruction with their own technological solutions. Four new companies believe they've staked out spaces ranging from operating alongside multi-billion dollar companies without facing crushing competition from them, to taking a more head-on competitive posture, and in each case, to make a clinical difference.

You may also be interested in...

Can ConforMIS Recharge Resurfacing with Custom Implants

Privately held ConforMIS Inc. is reintroducing customization to the large joint. It launched two new resurfacing tools this year and hopes to introduced a third, called iTotal, next year as a potential alternative to total knee implants.

SBI, ConforMIS Think and Act Globally in Search for Funds

Small Bone Innovations and ConforMIS drew capital from across the globe for their $144 million and $50 million financings.

MAKO Surgical: Navigating Robotics in Orthopedics

All but dead a half a dozen years ago, MAKO Surgical is alive and well with an innovative technology platform that both embraces robotics and looks past it. Key to MAKO's strategy: a focus on unicompartmental knee procedures that are extremely difficult to do manually but, company officials hope, are significantly enabled by its robotic arm platform. If company officials are right, MAKO's robotics system could help explode the unicompartmental segment of the knee market without cannibalizing the total knee replacement segment. This year's AAOS meeting was a kind of coming out party for MAKO, whose major challenge now is convincing surgeons that robotics is more than just an intriguing gadget-it's a critical part of the surgical armamentarium

Related Content


Related Companies

Related Deals

Latest Headlines
See All



Ask The Analyst

Ask the Analyst is free for subscribers.  Submit your question and one of our analysts will be in touch.

Your question has been successfully sent to the email address below and we will get back as soon as possible. my@email.address.

All fields are required.

Please make sure all fields are completed.

Please make sure you have filled out all fields

Please make sure you have filled out all fields

Please enter a valid e-mail address

Please enter a valid Phone Number

Ask your question to our analysts