CHF Solutions Inc.
This article was originally published in Start Up
Fluid overload is the number one reason why congestive heart failure patients end up in the hospital While diuretic drugs are the mainstays for eliminating excess fluid, they work slowly, often necessitating a 6-7 day stay in the hospital. CHF Solutions has an FDA cleared ultrafiltration device that can remove as much as four liters of fluid from a patient in 8 hours. Hospitals will save money, if they can cut patient hospital stays down by several days.
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Dialysis prolongs the lives of patients with end-stage renal disease, but outcomes are still poor, with a 17% mortality rate in the US. Nephrologists and technology developers want to improve outcomes, but the economics of dialysis have stymied innovation. Medicare tightly controls pricing, and developers are hard-pressed to find therapies that increase clinical benefits but not cost. Recently, two major clinical trials in dialysis hint that the benefits of dialysis, as it's currently performed, are approaching their limits. Start-ups now have the ammunition with which to approach a technologically stagnant market. Small companies, however, face daunting competition: three giant players dominate the market, two of which own 40% of the service centers that provide dialysis therapies.