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Neuromodulation Devices Stimulate Opportunities In Urology

Neuromodulation for urological indications, notably overactive bladder (OAB), has been dominated since the late 1990s by Medtronic’s sacral-nerve stimulation system InterStim, with the more recent addition of Cogentix Medical’s Urgent PC for tibial nerve stimulation. Yet only a fraction of OAB patients receive effective neuromodulation treatment, and several companies hope to lower barriers to this modality by developing alternative devices for urological indications.

Overactive bladder (OAB) afflicts hundreds of millions of adults worldwide, and an effective if underused third-line treatment is neuromodulation. The longtime market-dominant devices, Medtronic PLC’s InterStim and Cogentix Medical Inc.’s Urgent PC, now face competition from companies developing alternative approaches to neuromodulation for OAB and other urological indications. These companies see a multibillion-dollar market consisting largely of previously untreated patients.

InterStim, sometimes called the “bladder pacemaker,” is an implanted stimulator of the sacral nerve (sacral neuromodulation, or SNM). Urgent PC uses a less invasive approach called percutaneous tibial nerve stimulation...

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