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Despite Unknowns, Companies Bet On Transcatheter Mitral Valve Repair

Amid the success of transcatheter aortic valve replacement (TAVR), strategic acquisitions of transcatheter mitral valve replacement (TMVR) companies and the success of mitral valve repair device MitraClip, a group of companies are developing a number of minimally invasive options to repair mitral valves. Whether minimally invasive repair, replacement, or some combination will emerge as the best option for patients with mitral regurgitation remains unclear, and insiders say this road will be rockier than it was for TAVR.

The summer of 2015 saw massive strategic acquisitions by Edwards Lifesciences Corp., Medtronic PLC, HeartWare International Inc. and Abbott Laboratories Inc. of transcatheter mitral valve replacement devices [See Deal][See Deal][See Deal][See Deal]; also in 2015-- Abbott’s transcatheter mitral valve repair device MitraClip saw its 25,000th patient. The success of transcatheter aortic valve replacement (TAVR) has generated optimism in the industry that the much larger pool of mitral regurgitation (MR) patients can be similarly served.

While big strategics bet on replacement, however, other companies are betting on repair, developing less invasive devices inspired by an array of established mitral valve surgical repair techniques. These companies...

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