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Full Medtronic Results Offer Little Reason For Optimism On Renal Denervation

Renal denervation did not have a significant effect on systolic blood pressure in the SYMPLICITY HTN-3 trial, the first major sham-controlled trial of renal denervation for drug-resistant hypertension. The trial’s sponsor, Medtronic, had previously announced that it missed its primary endpoint but full results of the study were presented for the first time at the ACC meeting in Washington, DC on March 29.

Renal denervation, once thought by many to be the best hope for patients with uncontrolled hypertension, may not have a future at all. The full six-month results of SYMPLICITY HTN-3

sham-controlled data affirmed Medtronic PLC’s preliminary reports that its Symplicity catheter renal ablation system did not have a significant effect on systolic blood pressure in the trial.

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