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Studies Find Limited Support For Genotyping-Guided Warfarin Dosing

The overall message of three trials published recently in The New England Journal of Medicine: “This pharmacogenetic testing has either no usefulness in the initial dosing of vitamin K antagonists or, at best, marginal usefulness, given the cost and effort required to perform this testing,” according to an editorial also in NEJM.

The evidence in support of genetic-based dosing of coumarin anticoagulant drugs such as warfarin is mixed at best, based on the results of three studies published in The New England Journal of Medicine Nov. 19.

Warfarin (marketed by Bristol-Myers Squibb Co.under the name Coumadin),a vitamin K antagonist, is commonly used by cardiologists as an oral anticoagulant agent. But dosing of the drug is tricky...

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